Perianale streptogene Dermatitis: Penicillin oder Cephalosporin?

Penicillin and cephalosporin resistance in gonococci.

Non-penicillinase producing Neisseria gonorrhoeae isolated at St Mary's Hospital, London were examined for the prevalence of resistance to penicillin and for decreased susceptibility to cefuroxime. Of the 941 non-PPNG tested 100 (10.6%) were resistant to penicillin (minimum inhibitory concentration, MIC, greater than or equal to 1 mg/l) and were considered to be chromosomally-resistant N gonorr...

Cerebrospinal Fluid Concentrations of Penicillin and Cephalosporin Derivatives

Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose ...

Cephalosporin use in treatment of patients with penicillin allergies.

OBJECTIVE To review the evidence that supports the use of certain cephalosporins in penicillin-allergic patients. DATA SOURCES Published articles were identified through Medline and EMBASE (1960-2007) using the search terms penicillin and allergy and cephalosporin and cross-reactivity. Additional sources were identified from the authors' personal collection and the reference bibliographies. ...

Cephalosporin induced toxic epidermal necrolysis and subsequent penicillin drug exanthem.

BACKGROUND Drug hypersensitivity is classically divided into IgE mediated and non-IgE mediated disease. We report a rare case of consequent IgE mediated and non-IgE mediated reactions within the beta lactam class of antibiotics. CASE SUMMARY An 84-year-old man developed toxic epidermal necrolysis (TEN) due to ceftriaxone, a third generation cephalosporin, involving 72% of the body surface are...

Sodium Thiosulphate as an Antidote in Penicillin Exfoliative Dermatitis